Our research takes place at UNC Hospitals and is supported by the National Institute of Mental Health, the Foundation of Hope, the North Carolina Translational and Clinical Sciences Institute, and the Brain and Behavior Research Foundation.


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Perimenopausal Effects of Estradiol on Reward Response Study 

The purpose of this study is to examine the effects of estrogen on brain function and mood in women transitioning to menopause (the “perimenopause”). This study will allow us to explore the neural pathophysiology of perimenopausal depression, the effects of estrogen on the neural reward system, and the degree to which neural reward system dysfunction predicts the antidepressant effects of estrogen.

This study is currently recruiting participants.  This research study is seeking women with and without depression to participate in the study. The study involves wearing a low-dose estrogen patch for 3 weeks, having 2 fMRI brain scans, and coming to UNC for a total of 6 appointments.  For this research study, participants will receive a total of $500, and participants are responsible for their own transportation costs.

To see if you would be a good fit, please visit PEERSstudy.org or call Anita, at 919-966-5243.


For Additional Information

Visit our Contact Us page in order to leave a message with one of our lab members.

Visit our FAQ page for more detailed information about the study procedures.